Facile Access to Amides via Catalyst‐ and Additive‐Free Transamidation of N ‐Acylpyrrole‐Type Amides

Amides are key structural units in organic synthesis, essential for the efficient production of many pharmaceuticals and industrial chemicals. Transamidation enables one‐pot conversion between different amides. However, conventional methods are often hampered by toxic/corrosive reagents, strong acids/bases, or metal‐mediated conditions, which can lead to undesired hydrolysis. Here, a catalyst‐ and additive‐free transamidation of N ‐acylpyrrole‐type amides was developed. This method features mild conditions, operational simplicity, broad substrate scope, and excellent functional group compatibility.