What question did this study set out to answer?

This review aims to explore the use of redox-responsive nanoparticles to overcome barriers in mRNA delivery.

March 26, 2026Journal of Materials Chemistry B2 citations

Redox-Responsive Nanoparticles for Enhanced mRNA Delivery: A Comprehensive Review

ZWZiyue Wang BCBaiqiu ChenZhejiang University of Technology YGYuduo Gao

Puntos clave

This review aims to explore the use of redox-responsive nanoparticles to overcome barriers in mRNA delivery.
Analyzed current literature on mRNA delivery mechanisms.
Evaluated different types of nanoparticles and their effectiveness.
Assessed barriers to mRNA delivery including stability and cellular uptake.
Identified key challenges in mRNA delivery and their impact on vaccine efficacy.
Highlighted the advantages of redox-responsive nanoparticles for improving cellular uptake.
Noted the potential for increased therapeutic applications in future mRNA technologies.

Resumen

The clinical success of mRNA vaccines during the COVID-19 pandemic highlighted the therapeutic potential of mRNA while exposing persistent delivery barriers, including intrinsic instability, poor cellular uptake, and inefficient intracellular...

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