Redox-Responsive Nanoparticles for Enhanced mRNA Delivery: A Comprehensive Review

Ziyue Wang; Baiqiu Chen; Yuduo Gao; Chengfan Wu; Qi Shuai; Yunfeng Yan

doi:10.1039/d6tb00186f

January 1, 2026Journal of Materials Chemistry B

Redox-Responsive Nanoparticles for Enhanced mRNA Delivery: A Comprehensive Review

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Key Points

This review aims to explore the use of redox-responsive nanoparticles to overcome barriers in mRNA delivery.
Analyzed current literature on mRNA delivery mechanisms.
Evaluated different types of nanoparticles and their effectiveness.
Assessed barriers to mRNA delivery including stability and cellular uptake.
Identified key challenges in mRNA delivery and their impact on vaccine efficacy.
Highlighted the advantages of redox-responsive nanoparticles for improving cellular uptake.
Noted the potential for increased therapeutic applications in future mRNA technologies.

Implication

A comprehensive review demonstrates enhanced mRNA delivery in varied contexts, suggesting improved vaccine efficacy.

Abstract

The clinical success of mRNA vaccines during the COVID-19 pandemic highlighted the therapeutic potential of mRNA while exposing persistent delivery barriers, including intrinsic instability, poor cellular uptake, and inefficient intracellular...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd80fdc3bde448919ee1 https://doi.org/10.1039/d6tb00186f

View at Publisher

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Redox-Responsive Nanoparticles for Enhanced mRNA Delivery: A Comprehensive Review

Key Points

Implication

Abstract

Discussion

Cite This Study

Redox-Responsive Nanoparticles for Enhanced mRNA Delivery: A Comprehensive Review

Key Points

Implication

Abstract

Discussion

Cite This Study

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