What question did this study set out to answer?

The aim is to explore how allyl isothiocyanate (AITC) affects collagen-induced arthritis (CIA) through mast cell targeting and Pim1 pathway activation.

March 28, 2026

Allyl isothiocyanate ameliorates collagen-induced arthritis via mast cells and the pim1 pathway

Puntos clave

The aim is to explore how allyl isothiocyanate (AITC) affects collagen-induced arthritis (CIA) through mast cell targeting and Pim1 pathway activation.
Examined the role of mast cells in AITC treatment.
Analyzed the impact of AITC on collagen-induced arthritis progression.
Investigated the Pim1 signaling pathway in mast cell activation.
AITC significantly suppresses mast cell activation in CIA.
Pim1-related signaling appears essential for AITC's effectiveness.
Mast cells are identified as a vital target for AITC in inflammatory response.

Resumen

These findings support mast cell as a major cellular target of AITC in CIA and suggest that Pim1-related signaling contributes to AITC-mediated suppression of mast cell activation.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Hao Wang

General Cardiology

Yiying Wang

Nankai University

Ronghao Zhang

Journals

Journal of Pharmacy and Pharmacology

Actions

Institutions

University of Toyama

Shanghai University of Traditional Chinese Medicine

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Allyl isothiocyanate ameliorates collagen-induced arthritis via mast cells and the pim1 pathway

Puntos clave

Resumen

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider