Allyl isothiocyanate ameliorates collagen-induced arthritis via mast cells and the pim1 pathway
Key Points
The aim is to explore how allyl isothiocyanate (AITC) affects collagen-induced arthritis (CIA) through mast cell targeting and Pim1 pathway activation.
Examined the role of mast cells in AITC treatment.
Analyzed the impact of AITC on collagen-induced arthritis progression.
Investigated the Pim1 signaling pathway in mast cell activation.
AITC significantly suppresses mast cell activation in CIA.
Pim1-related signaling appears essential for AITC's effectiveness.
Mast cells are identified as a vital target for AITC in inflammatory response.
Abstract
These findings support mast cell as a major cellular target of AITC in CIA and suggest that Pim1-related signaling contributes to AITC-mediated suppression of mast cell activation.