Increases in total HIV-1 nucleic acid in whole blood precede plasma rna rebound during paediatric analytical treatment interruption
Puntos clave
The study aims to identify how increases in HIV-1 nucleic acid in whole blood relate to plasma RNA rebound during treatment interruptions in children.
Conducted point-of-care HIV-1 total nucleic acid testing in pediatric population during analytical treatment interruption.
Monitored increases in whole blood HIV-1 nucleic acid levels to predict plasma viral rebound.
Evaluated the effectiveness of lower-volume testing for rapid detection.
Increased whole blood HIV-1 nucleic acid was observed prior to any plasma RNA rebound.
Point-of-care testing improved the speed of monitoring for viral rebound, enhancing safety measures.
Timely detection allowed for quicker initiation of antiretroviral therapy.
Resumen
PoC HIV-1 TNA testing offers a more rapid and lower-volume method to detect viral rebound in paediatric ATI, enhancing safety monitoring and timely ART reinitiation.