Increases in total HIV-1 nucleic acid in whole blood precede plasma rna rebound during paediatric analytical treatment interruption

Gabriela Cromhout; Nomonde Bengu; Nicholas Herbert; Rowena Fillis; Samantha Kannie; Jeroen van Lobenstein; Kogielambal Chinniah; Malini Krishna; Roopesh Bhoola; Noxolo Mahlaba; Maria C. Garcia-Guerrero; Thumbi Ndung’u; M. C. Puertas; Javier Martinez-Picado; Moherndran Archary; Philip JR Goulder

doi:10.1097/qad.0000000000004506

March 26, 2026AIDS

Increases in total HIV-1 nucleic acid in whole blood precede plasma rna rebound during paediatric analytical treatment interruption

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Key Points

The study aims to identify how increases in HIV-1 nucleic acid in whole blood relate to plasma RNA rebound during treatment interruptions in children.
Conducted point-of-care HIV-1 total nucleic acid testing in pediatric population during analytical treatment interruption.
Monitored increases in whole blood HIV-1 nucleic acid levels to predict plasma viral rebound.
Evaluated the effectiveness of lower-volume testing for rapid detection.
Increased whole blood HIV-1 nucleic acid was observed prior to any plasma RNA rebound.
Point-of-care testing improved the speed of monitoring for viral rebound, enhancing safety measures.
Timely detection allowed for quicker initiation of antiretroviral therapy.

Implication

Analyzing viral rebound in children during treatment interruptions suggests smarter monitoring methods.

Abstract

PoC HIV-1 TNA testing offers a more rapid and lower-volume method to detect viral rebound in paediatric ATI, enhancing safety monitoring and timely ART reinitiation.

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Cite This Study

Cromhout et al. (2026) studied this question.

synapsesocial.com/papers/69c8c2e4de0f0f753b39d63d https://doi.org/10.1097/qad.0000000000004506

View at Publisher

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Increases in total HIV-1 nucleic acid in whole blood precede plasma rna rebound during paediatric analytical treatment interruption

Key Points

Implication

Abstract

Discussion

Cite This Study

Increases in total HIV-1 nucleic acid in whole blood precede plasma rna rebound during paediatric analytical treatment interruption

Key Points

Implication

Abstract

Discussion

Cite This Study

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