Using HIV antibody measurements to detect viral load rebound: analysis from an analytic treatment interruption study in the United States

Q: What does this research mean for the field?

Longitudinal measurements of LAg antibodies can effectively indicate viral load rebound in HIV treatment interruption. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Anna Bershteyn; Shiying You; Adam Epstein-Shuman; Zoe Gotthold; Hae-Young Kim; Nao Yamamoto; David Kaftan; Tae-Wook Chun; Oliver Laeyendecker

doi:10.1016/j.ijid.2026.108499

March 1, 2026International Journal of Infectious DiseasesOpen Access

Using HIV antibody measurements to detect viral load rebound: analysis from an analytic treatment interruption study in the United States

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Key Points

This study aims to evaluate the relationship between HIV antibody levels and viral load rebound during treatment interruptions.
Participants underwent treatment interruption with follow-up measuring HIV antibody levels and viral load over 2-4 weeks.
Longitudinal analysis of antibody levels was performed to assess their correlation with viral load detection.
LAg antibody levels increased in all participants within 2-4 weeks after viral load detection.
Consistent longitudinal measurements of antibodies were identified as viable for rapid HIV treatment monitoring.

Implication

Analyzes HIV antibody levels and viral load rebound in participants, suggesting effective monitoring strategy.

Abstract

LAg antibody levels rose in all participants 2-4 weeks after VL detection in treatment interruption. Longitudinal antibody measurements could support facile, rapid, low-cost HIV treatment monitoring.

Discussion

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Cite This Study

Bershteyn et al. (2026) studied this question.

synapsesocial.com/papers/69ada804bc08abd80d5bb1f8 https://doi.org/10.1016/j.ijid.2026.108499

View Full Paper

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Using HIV antibody measurements to detect viral load rebound: analysis from an analytic treatment interruption study in the United States

Key Points

Implication

Abstract

Discussion

Cite This Study

Using HIV antibody measurements to detect viral load rebound: analysis from an analytic treatment interruption study in the United States

Key Points

Implication

Abstract

Discussion

Cite This Study

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