Is the KCNH2-K897T genetic variant associated with a higher incidence of atrial fibrillation?
The KCNH2-K897T variant is associated with a higher incidence of atrial fibrillation, providing a molecular correlate for complex genetic predispositions to the disease.
We report a genetic association finding including positive replication between the K897-allele and higher incidence of AF. This provides a molecular correlate for complex genetic predispositions to AF. The consequences of the K897T variant at the atrial level will require further functional investigations.
Sinner et al. (Fri,) studied this question.