Key result
KCNH2-K897T genetic variant K897-allele is linked to increased risk of incident atrial fibrillation.
Why the study?
A molecular correlate for complex genetic predispositions to atrial fibrillation was lacking, motivating analysis of the KCNH2-K897T variant.
Is the KCNH2-K897T genetic variant associated with a higher incidence of atrial fibrillation?
Is the KCNH2-K897T genetic variant associated with a higher incidence of atrial fibrillation?
Answers are grounded in this paper and cite their sources.
The KCNH2-K897T variant is associated with a higher incidence of atrial fibrillation, providing a molecular correlate for complex genetic predispositions to the disease.
We report a genetic association finding including positive replication between the K897-allele and higher incidence of AF. This provides a molecular correlate for complex genetic predispositions to AF. The consequences of the K897T variant at the atrial level will require further functional investigations.
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Sinner et al. (2008) studied this question. The K897-allele of the KCNH2-K897T variant is associated with a higher incidence of atrial fibrillation.
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