What question did this study set out to answer?

This research aims to explore how GLUT1 expression in different compartments of colorectal liver metastases (CRLM) relates to patient outcomes.

April 8, 2026Open Access

Compartment-specific GLUT1 patterns in colorectal liver metastases: invasive-margin GLUT1 associates with outcome in solitary disease

Puntos clave

This research aims to explore how GLUT1 expression in different compartments of colorectal liver metastases (CRLM) relates to patient outcomes.
Analyzed GLUT1 expression patterns in tumor-core and invasive-margin regions of CRLM using immunofluorescence.
Examined the relationship between GLUT1 expression and patient outcomes in solitary metastases.
Proposed further validation through quantitative spatial immune profiling and independent cohorts.
Found a link between tumor-core GLUT1 and tumor proliferation.
Identified invasive-margin GLUT1 as a marker associated with favorable patient outcomes in solitary metastases.
Highlights the need for further quantitative analysis to confirm findings.

Resumen

GLUT1 shows compartment- and context-dependent associations in the CRLM. While tumor-core GLUT1 is linked to proliferative activity, invasive-margin GLUT1 is associated with favorable outcomes in solitary metastases. Immunofluorescence and functional data provide hypothesis-generating context and warrant validation with quantitative spatial immune profiling and independent cohorts.

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