Compartment-specific GLUT1 patterns in colorectal liver metastases: invasive-margin GLUT1 associates with outcome in solitary disease

Eva Grießhammer; Niklas Bogovic; Edward K. Geissler; Katja Evert; Markus Götz; Christina Hackl; S. Fichtner-Feigl; H J Schlitt; Stefan M. Brunner

doi:10.1007/s00262-026-04378-z

April 6, 2026Cancer Immunology ImmunotherapyOpen Access

Compartment-specific GLUT1 patterns in colorectal liver metastases: invasive-margin GLUT1 associates with outcome in solitary disease

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Key Points

This research aims to explore how GLUT1 expression in different compartments of colorectal liver metastases (CRLM) relates to patient outcomes.
Analyzed GLUT1 expression patterns in tumor-core and invasive-margin regions of CRLM using immunofluorescence.
Examined the relationship between GLUT1 expression and patient outcomes in solitary metastases.
Proposed further validation through quantitative spatial immune profiling and independent cohorts.
Found a link between tumor-core GLUT1 and tumor proliferation.
Identified invasive-margin GLUT1 as a marker associated with favorable patient outcomes in solitary metastases.
Highlights the need for further quantitative analysis to confirm findings.

Implication

Research demonstrates invasive-margin GLUT1 predicts outcomes in solitary colorectal liver metastases, suggesting clinical significance.

Abstract

GLUT1 shows compartment- and context-dependent associations in the CRLM. While tumor-core GLUT1 is linked to proliferative activity, invasive-margin GLUT1 is associated with favorable outcomes in solitary metastases. Immunofluorescence and functional data provide hypothesis-generating context and warrant validation with quantitative spatial immune profiling and independent cohorts.

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Cite This Study

Grießhammer et al. (2026) studied this question.

synapsesocial.com/papers/69d5f0ee74eaea4b11a7a6f2 https://doi.org/10.1007/s00262-026-04378-z

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Compartment-specific GLUT1 patterns in colorectal liver metastases: invasive-margin GLUT1 associates with outcome in solitary disease

Key Points

Implication

Abstract

Discussion

Cite This Study

Compartment-specific GLUT1 patterns in colorectal liver metastases: invasive-margin GLUT1 associates with outcome in solitary disease

Key Points

Implication

Abstract

Discussion

Cite This Study

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