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September 10, 2025npj Precision OncologyOpen Access

Intratumoral microbial community profiling identifies clinicomolecular and prognostic subtypes of colorectal cancer liver metastasis

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Intratumoral microbial community profiling identifies three subtypes related to colorectal cancer liver metastasis.
Patients with subtype IMCS1 showed median disease-free survival of 22 months, the highest among the identified groups.
5R 16S rRNA gene sequencing was utilized to analyze the microbiota of colorectal cancer patients with and without liver metastasis.
This research highlights the potential for microbiota-directed therapies to improve survival outcomes in colorectal cancer.

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Analysis identifies three intratumoral microbial community subtypes in colorectal cancer liver metastasis, suggesting new therapeutic pathways.

Yan et al. (2025) studied this question.

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Analysis identifies three intratumoral microbial community subtypes in colorectal cancer liver metastasis, suggesting new therapeutic pathways.