Are changes in plasma BNP and norepinephrine over time associated with mortality and morbidity in heart failure patients?
Changes in BNP and norepinephrine over time are significant predictors of mortality and morbidity in heart failure, reinforcing their utility as surrogate markers in clinical trials.
Not only are plasma BNP and NE important predictors of heart failure M&M, but changes in these neurohormones over time are associated with corresponding changes in M&M. These data further reinforce their role as significant surrogate markers in HF and underscore the importance of including their measurement in HF trials.
Anand et al. (Mon,) studied this question.