March 10, 2003Circulation
Changes in Brain Natriuretic Peptide and Norepinephrine Over Time and Mortality and Morbidity in the Valsartan Heart Failure Trial (Val-HeFT)
Why the study?
Are changes in plasma BNP and norepinephrine over time associated with mortality and morbidity in heart failure patients?
Population
Heart failure patients in the Valsartan Heart Failure Trial (Val-HeFT)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Serial BNP/NE monitoring may aid HF risk stratification; leaves open validation as trial surrogates.
Structured PICO
Are changes in plasma BNP and norepinephrine over time associated with mortality and morbidity in heart failure patients?
P
Population
Heart failure patients in the Valsartan Heart Failure Trial (Val-HeFT)
I
Intervention
Measurement of changes in plasma Brain Natriuretic Peptide (BNP) and Norepinephrine (NE) over time
O
Outcome
Mortality and morbidityhard clinical
Changes in BNP and norepinephrine over time are significant predictors of mortality and morbidity in heart failure, reinforcing their utility as surrogate markers in clinical trials.
Cite This Study
Anand et al. (2003) studied this question.