February 25, 2019Open Access

Association Between Antibiotic Use and Hospital-onset Clostridioides difficile Infection in US Acute Care Hospitals, 2006–2012: An Ecologic Analysis

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Resumen

At an ecologic level, reductions in total AU, use of fluoroquinolones, and use of third- and fourth-generation cephalosporins were each associated with decreased HO-CDI rates.

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Cite This Study

Kazakova et al. (Mon,) studied this question.

synapsesocial.com/papers/69d72ffcb54ccf0cfef306d4 https://doi.org/https://doi.org/10.1093/cid/ciz169

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1Presence of Clostridium difficile and antibiotic and beta-lactamase activities in feces of volunteers treated with oral cefixime, oral cefpodoxime proxetil, or placebo1992 · 45 citations
2Imported Disease Pressure and Bulk Antibiotic Use: Novel Predictors of Facility-Level C. Difficile Infection (CDI) Incidence in the United States Veterans Health Administration2015 · 1 citations
3Antibiotic Treatment of <i>Clostridium difficile</i> Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts2009 · 357 citations
4Prospective study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery1991 · 161 citations
5Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)2018 · 1,157 citations

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