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TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer | Synapse

April 14, 2023Open Access

TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer

AKAditi S. KhatpeStanford Medicine RDRebecca DirksDuke University PBPoornima Bhat‐NakshatriIndiana University – Purdue University Indianapolis

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Resumen

The chr.8q24.3 amplicon-resident gene TONSL is upregulated during the initial steps of tumorigenesis to support neoplastic transformation by increasing DNA repair and represents a potential therapeutic target for treating breast cancer.

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Khatpe et al. (Fri,) studied this question.

synapsesocial.com/papers/69d75f81aa68b335b4f3123d https://doi.org/https://doi.org/10.1158/0008-5472.can-22-3667