TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer

Aditi S. Khatpe; Rebecca Dirks; Poornima Bhat‐Nakshatri; Henry Mang; Katie Batic; Sarah Swiezy; Jacob Duane Olson; Xi Rao; Yue Wang; Hiromi Tanaka; Sheng Liu; Jun Wan; Duojiao Chen; Yunlong Liu; Fang Fang; Sandra K. Althouse; Emily Hulsey; Maggie M. Granatir; Rebekah Addison; Constance J. Temm; George E. Sandusky; Audrey Lee‐Gosselin; Kenneth P. Nephew; Kathy D. Miller; Harikrishna Nakshatri

doi:10.1158/0008-5472.can-22-3667

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Abstract

The chr.8q24.3 amplicon-resident gene TONSL is upregulated during the initial steps of tumorigenesis to support neoplastic transformation by increasing DNA repair and represents a potential therapeutic target for treating breast cancer.

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Khatpe et al. (2023) studied this question.

synapsesocial.com/papers/69d75f81aa68b335b4f3123d https://doi.org/10.1158/0008-5472.can-22-3667

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TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer

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Abstract

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TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer

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Abstract

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