Does TGF-β1 alter mitochondrial content and cellular respiration during the differentiation of fibroblasts?
TGF-β1-mediated fibroblast differentiation involves energetic remodeling characterized by increased mitochondrial content and respiration.
TGF-β1 induced differentiation of fibroblasts is accompanied by energetic remodeling of myofibroblasts with an increase in mitochondrial respiration and mitochondrial content.
Negmadjanov et al. (Tue,) studied this question.