Periostin facilitates skin sclerosis via a PI3K/Akt dependent mechanism, highlighting it as a potential therapeutic target for human scleroderma.
Periostin plays an essential role in the pathogenesis of Bleomycin-induced scleroderma in mice. Periostin may represent a potential therapeutic target for human scleroderma.
Yang et al. (Tue,) studied this question.