Periostin facilitates skin sclerosis via a PI3K/Akt dependent mechanism, highlighting it as a potential therapeutic target for human scleroderma.
Periostin-PI3K/Akt merits targeting in scleroderma models; mouse data leave open human translation.
Periostin plays an essential role in the pathogenesis of Bleomycin-induced scleroderma in mice. Periostin may represent a potential therapeutic target for human scleroderma.
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Yang et al. (2012) studied this question.
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