Why the study?
Does MMP inhibition with PD-166793 improve left ventricular remodeling in wild-type and TIMP-1 knockout mice after myocardial infarction?
Does MMP inhibition with PD-166793 improve left ventricular remodeling in wild-type and TIMP-1 knockout mice after myocardial infarction?
Myocardial TIMP-1 plays a critical regulatory role in post-MI remodeling, and the accelerated adverse remodeling induced by TIMP-1 deficiency can be pharmacologically rescued by MMP inhibition.
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Caution against clinical translation of MMP inhibition post-MI; extends preclinical evidence on TIMP-1 regulation of remodeling.
Ikonomidis et al. (2004) studied this question.
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