August 20, 1999Circulation ResearchOpen Access

Matrix Metalloproteinase Inhibition During the Development of Congestive Heart Failure

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Why the study?

Does matrix metalloproteinase inhibition with PD166793 limit left ventricular dilation and remodeling in a pig model of pacing-induced congestive heart failure?

Structured PICO

Does matrix metalloproteinase inhibition with PD166793 limit left ventricular dilation and remodeling in a pig model of pacing-induced congestive heart failure?

Population

Pigs subjected to rapid pacing (240 bpm) for 3 weeks to induce congestive heart failure (n=33 total: 12 CHF, 10 CHF/MMPi, 11 control)

Intervention

Matrix metalloproteinase inhibition (MMPi) with PD166793 (20 mg/kg per day) concomitant with rapid pacing for 3 weeks

Comparator

CHF-only (rapid pacing without MMPi) and unpaced controls

Outcome

Left ventricular size and function (fractional shortening, end-diastolic dimension) during the progression of CHFsurrogate

Chronic matrix metalloproteinase inhibition limited left ventricular dilation and reduced wall stress in a pig model of pacing-induced heart failure, suggesting MMP activity directly contributes to myocardial remodeling.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

MMP inhibition attenuates remodeling in experimental HF; hypothesis-generating for clinical translation, no practice change yet.

Cite This Study

Spinale et al. (1999) studied this question.

synapsesocial.com/papers/69f53f53e0fbb6efbd203975 https://doi.org/10.1161/01.res.85.4.364

Topics

Heart failure HFrEF treatment

View Full Paper

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Matrix Metalloproteinase Inhibition During the Development of Congestive Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Topics

Matrix Metalloproteinase Inhibition During the Development of Congestive Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider