Activation of the PI3K/AKT cell survival cascade may explain the rapid regeneration and protection from cell death seen in Tako-Tsubo cardiomyopathy.
PI3K/AKT signalling is activated in TTC. This activated cell survival cascade might protect cardiomyocytes from cell death and also contribute to rapid regeneration in TTC.
Nef et al. (Fri,) studied this question.