Specific dystrophin gene mutations may predict the development of dilated cardiomyopathy in patients with muscular dystrophy, highlighting the potential importance of early diagnosis and intervention.
Early diagnosis and treatment of DCM may lead to ventricular remodeling in DMD/BMD patients. Specific dystrophin gene mutations appear to be predictive of cardiac involvement, while other mutations may protect against or inhibit development of DCM. Further studies evaluating the impact of early intervention strategies on left ventricular geometry and function in muscular dystrophy patients seem warranted.
Jefferies et al. (Wed,) studied this question.
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