A liberal perioperative fluid management approach was associated with postoperative NPPA/SDC1 upregulation, suggesting a stress response affecting glycocalyx integrity.
Observational
Does a liberal approach to perioperative fluid management affect glycocalyx injury in patients undergoing major urological oncology surgeries?
Genetic readouts such as NPPA-SDC1 may be useful for perioperative monitoring of glycocalyx injury related to fluid management strategies.
The association of the liberal approach with postoperative NPPA/SDC1 upregulation suggests a transcriptional-level stress/damage response affecting glycocalyx integrity. These findings suggest that genetic readouts (NPPA-SDC1 and exploratory HPSE/HAS2) may be useful for perioperative monitoring and generate hypotheses for further studies integrating multi-timepoint protein/ectodomain measurements.
Kivanc et al. (Fri,) conducted a observational in Major urological oncology surgeries. Liberal perioperative fluid management was evaluated on Postoperative NPPA/SDC1 upregulation. A liberal perioperative fluid management approach was associated with postoperative NPPA/SDC1 upregulation, suggesting a stress response affecting glycocalyx integrity.