Key result
Liberal perioperative fluid management linked to postoperative NPPA/SDC1 upregulation, suggesting impaired glycocalyx integrity.
Why the study?
Does a liberal approach to perioperative fluid management affect glycocalyx injury in patients undergoing major urological oncology surgeries?
Observational
Does a liberal approach to perioperative fluid management affect glycocalyx injury in patients undergoing major urological oncology surgeries?
Genetic readouts such as NPPA-SDC1 may be useful for perioperative monitoring of glycocalyx injury related to fluid management strategies.
Answers are grounded in this paper and cite their sources.
Warrants caution against liberal fluids in urological oncology surgery to limit glycocalyx injury; hypothesis-generating for NPPA/SDC1 monitoring in perioperative care.
The association of the liberal approach with postoperative NPPA/SDC1 upregulation suggests a transcriptional-level stress/damage response affecting glycocalyx integrity. These findings suggest that genetic readouts (NPPA-SDC1 and exploratory HPSE/HAS2) may be useful for perioperative monitoring and generate hypotheses for further studies integrating multi-timepoint protein/ectodomain measurements.
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Kivanc et al. (2026) conducted an observational in Major urological oncology surgeries. Liberal perioperative fluid management was evaluated on Postoperative NPPA/SDC1 upregulation. A liberal perioperative fluid management approach was associated with postoperative NPPA/SDC1 upregulation, suggesting a stress response affecting glycocalyx integrity.
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