Are single nucleotide polymorphisms in thrombospondin genes associated with familial premature myocardial infarction?
Genetic variants in the thrombospondin gene family may play a role in familial premature myocardial infarction, highlighting a potential area for further genomic study.
This large-scale genetic study has identified the potential of multiple novel variants in the thrombospondin gene family to be associated with familial premature myocardial infarction. Notwithstanding multiple caveats, thrombospondins specifically and high-throughput genomic technology in general deserve further study in familial ischemic heart disease.
Topol et al. (Tue,) studied this question.