What question did this study set out to answer?

The aim is to synthesize a novel class of compounds, specifically substituted 1,7-dihydropyrazolo[4,3-b][1,4]selenazinones.

April 16, 2026

Construction of 2H-1,4-selenazin-3(4H)-one framework via cyclization of pyrazole derivatives bearing chloroacetamide and selenocyanate fragments

TKTatiana A KudryavtsevaN.D. Zelinsky Institute of Organic Chemistry EKEkaterina KudryavtsevaN.D. Zelinsky Institute of Organic Chemistry BLBoris V. LichitskyN.D. Zelinsky Institute of Organic Chemistry

Puntos clave

The aim is to synthesize a novel class of compounds, specifically substituted 1,7-dihydropyrazolo[4,3-b][1,4]selenazinones.
Developed a three-step synthesis method.
Started from readily available 5-aminopyrazoles.
Utilized cyclization of pyrazole derivatives with chloroacetamide and selenocyanate.
Successfully synthesized substituted 1,7-dihydropyrazolo[4,3-b][1,4]selenazin-6(5H)-ones.
The method is efficient and can be applied to various pyrazole derivatives.

Resumen

For the first time, we developed an efficient three-step method for the synthesis of substituted 1,7-dihydropyrazolo4,3-b1,4selenazin-6(5H)-ones starting from readily accessible 5-aminopyrazoles. The presented approach is based on preliminary preparation of...

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