Deep cerebellar stimulation restores chronic motor deficits and loss of GABAergic neurons following sensorimotor cortex surgical brain injury in female rats

Puntos clave

• The aim is to investigate the effects of deep cerebellar stimulation on motor recovery and GABAergic neuron loss after brain injury.
• Conducted experiments on female rats with sensorimotor cortex surgical brain injury.
• Applied LCN-DBS to assess its impact on motor function and neuron recovery.
• Analyzed changes in GABAergic neurotransmission in the perilesional cortex.
• LCN-DBS significantly improved motor recovery post-brain injury.
• Restoration of GABAergic neurons was observed.
• The findings support LCN-DBS as a viable therapeutic option for motor rehabilitation.