Deep cerebellar stimulation restores chronic motor deficits and loss of GABAergic neurons following sensorimotor cortex surgical brain injury in female rats

Minkyung Kim; Hugh H. Chan; Brittany Fisher; Nandini Bangalore; Molly Shamah; Sophie Shimeall; Nymisha Mandava; Olivia Hogue; André G. Machado; Kenneth B. Baker

doi:10.1016/j.expneurol.2026.115779

April 1, 2026Experimental NeurologyOpen Access

Deep cerebellar stimulation restores chronic motor deficits and loss of GABAergic neurons following sensorimotor cortex surgical brain injury in female rats

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to investigate the effects of deep cerebellar stimulation on motor recovery and GABAergic neuron loss after brain injury.
Conducted experiments on female rats with sensorimotor cortex surgical brain injury.
Applied LCN-DBS to assess its impact on motor function and neuron recovery.
Analyzed changes in GABAergic neurotransmission in the perilesional cortex.
LCN-DBS significantly improved motor recovery post-brain injury.
Restoration of GABAergic neurons was observed.
The findings support LCN-DBS as a viable therapeutic option for motor rehabilitation.

Implication

Demonstrates motor recovery in female rats after brain surgery, suggesting deep cerebellar stimulation's potential.

Abstract

LCN-DBS promotes motor recovery following SBI, potentially by modulating GABAergic neurotransmission in perilesional cortex. These findings further support LCN-DBS as a promising therapeutic intervention for motor rehabilitation following SBI, particularly in female subjects who are underrepresented in neuroscience research.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69e4702d010ef96374d8d6da https://doi.org/10.1016/j.expneurol.2026.115779

View Full Paper

Ask AI

Bookmark

Share

Deep cerebellar stimulation restores chronic motor deficits and loss of GABAergic neurons following sensorimotor cortex surgical brain injury in female rats

Key Points

Implication

Abstract

Discussion

Cite This Study

Deep cerebellar stimulation restores chronic motor deficits and loss of GABAergic neurons following sensorimotor cortex surgical brain injury in female rats

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading