Association Between Cardiovascular Polygenic Risk and White Matter Hyperintensities: An Observational Study From the UK Biobank

Puntos clave

• This research aims to explore how genetic factors influence the relationship between cardiovascular risk and white matter hyperintensities.
• Observational study using data from the UK Biobank
• Analysis of cardiovascular polygenic risk scores
• Assessment of white matter hyperintensity burden
• Found a clear association between higher polygenic risk and increased white matter hyperintensity burden
• Supports the role of genetic background in cardiovascular disease risk