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PTEN: Regulation, Signalling and Targeting in Cancer | Synapse

April 24, 2026Open Access

PTEN: Regulation, Signalling and Targeting in Cancer

Puntos clave

The aim is to explore the regulation and signaling role of PTEN in cancer development and treatment.
Literature review of existing studies on PTEN's function and signaling pathways.
Analysis of PTEN mutations and their implications in various cancer types.
Discussion on therapeutic strategies targeting PTEN signaling.
PTEN acts as a critical tumor suppressor, affecting cancer cell growth and survival.
Alterations in PTEN are linked to multiple cancer types, indicating its role in tumor progression.
Targeting PTEN signaling pathways could provide new therapeutic options for cancer treatment.

Resumen

PTEN (phosphatase and tensin homolog deleted on chromosome ten)/MMAC1 (mutated in multiple advanced cancers) was discovered by two groups in 1997 as a novel tumor suppressor gene located at chromosome 10q23 ...

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Cite This Study

Kotelevets et al. (Wed,) studied this question.

synapsesocial.com/papers/69eb0bc7553a5433e34b5504 https://doi.org/https://doi.org/10.3390/cancers18091320