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April 22, 2026CancersOpen Access

PTEN: Regulation, Signalling and Targeting in Cancer

Larissa Kotelevets Mark G. H. Scott Eric Chastre

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Key Points

The aim is to explore the regulation and signaling role of PTEN in cancer development and treatment.
Literature review of existing studies on PTEN's function and signaling pathways.
Analysis of PTEN mutations and their implications in various cancer types.
Discussion on therapeutic strategies targeting PTEN signaling.
PTEN acts as a critical tumor suppressor, affecting cancer cell growth and survival.
Alterations in PTEN are linked to multiple cancer types, indicating its role in tumor progression.
Targeting PTEN signaling pathways could provide new therapeutic options for cancer treatment.

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Implication

This research uncovers how PTEN regulates signaling in cancer, suggesting new therapeutic targets.

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Cite This Study

Kotelevets et al. (2026) studied this question.

synapsesocial.com/papers/69eb0bc7553a5433e34b5504 https://doi.org/10.3390/cancers18091320

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase ActivityReview · 1999 · 542 citations
2PTEN defects in cancer, from gene to protein molecular causes and therapeutic targets2025 · 6 citations
3PTEN: Multiple Functions in Human Malignant TumorsReview · 2015 · 465 citations
4The Biology and Clinical Relevance of the <i>PTEN</i> Tumor Suppressor PathwayEarly-Phase Clinical Trial · 2004 · 921 citations
5P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseOriginal Research · 1997 · 775 citations

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