February 2, 1999Open Access

Cardiac Myocytes Produce Interleukin-6 in Culture and in Viable Border Zone of Reperfused Infarctions

PICO estructurado

Población

Isolated cardiac myocytes in culture and in vivo model of reperfused myocardial infarction

Intervención

Exposure to cytokines and postischemic cardiac lymph

Resultado

IL-6 mRNA productionsurrogate

Demonstrates that cardiac myocytes are an active source of IL-6 production in the setting of myocardial infarction and reperfusion.

Resumen

Isolated cardiac myocytes produce IL-6 mRNA in response to several cytokines as well as postischemic cardiac lymph. In addition to its production by inflammatory cells, we demonstrate that IL-6 mRNA is induced in myocytes in the viable border zone of a myocardial infarct. The potential roles of IL-6 in cardiac myocytes in an infarct border are discussed.

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Cite This Study

Gwechenberger et al. (Tue,) studied this question.

synapsesocial.com/papers/69eff9c7bce9831ba4f7386a https://doi.org/https://doi.org/10.1161/01.cir.99.4.546

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1994 · 1,346 citations