Key result
Postischemic lymph triggers cardiac myocyte IL-6 production specifically within the viable infarct border zone.
Why the study?
The production of IL-6 by cardiac myocytes in response to cytokines and in the viable border zone of myocardial infarction was not fully characterized.
Demonstrates that cardiac myocytes are an active source of IL-6 production in the setting of myocardial infarction and reperfusion.
Myocyte IL-6 production may fuel post-MI inflammation; hypothesis-generating in animals and leaves open human relevance.
Isolated cardiac myocytes produce IL-6 mRNA in response to several cytokines as well as postischemic cardiac lymph. In addition to its production by inflammatory cells, we demonstrate that IL-6 mRNA is induced in myocytes in the viable border zone of a myocardial infarct. The potential roles of IL-6 in cardiac myocytes in an infarct border are discussed.
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Gwechenberger et al. (1999) studied this question. Cardiac myocytes produce IL-6 mRNA in response to cytokines and postischemic lymph, with induction specifically occurring in the viable border zone of a myocardial infarct.
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