Does ACE inhibition prevent the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure?
ACE inhibition interferes with signal transduction leading to the AF substrate in a canine model of CHF, suggesting a potential role in AF therapy.
CHF-induced increases in angiotensin II content and MAPK activation contribute to arrhythmogenic atrial structural remodeling. ACE inhibition interferes with signal transduction leading to the AF substrate in CHF and may represent a useful new component to AF therapy.
Li et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: