Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure
Why the study?
Does ACE inhibition prevent the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure?
Population
Dogs with ventricular tachypacing-induced congestive heart failure
Design
Preclinical
Authors
Discussion
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Member takes
Implication
ACE inhibition merits clinical investigation for AF prevention in CHF; hypothesis-generating in canine models and leaves open human translation.
Structured PICO
Does ACE inhibition prevent the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure?
P
Population
Dogs with ventricular tachypacing-induced congestive heart failure
I
Intervention
Angiotensin-Converting Enzyme (ACE) inhibition
O
Outcome
Development of the atrial fibrillation substrate and arrhythmogenic atrial structural remodelingsurrogate
ACE inhibition interferes with signal transduction leading to the AF substrate in a canine model of CHF, suggesting a potential role in AF therapy.
Cite This Study
Li et al. (2001) studied this question.