Effect of Free and Nanoparticle-Based Vitamin C and Curcumin on Renal Function, Lipid Profile, and Kidney Histology in Adenine-induced Chronic Kidney Disease in Male Wistar Rats

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• This research aims to determine how free and nanoparticle-based vitamin C and curcumin affect kidney function, lipid levels, and kidney tissue in a chronic kidney disease model.
• Used adenine-induced chronic kidney disease model in male Wistar rats.
• Administered free and nanoparticle formulations of vitamin C and curcumin.
• Evaluated renal function, lipid profile, and kidney histology post-treatment.
• Vitamin C and curcumin improved renal function markers significantly (p<0.05).
• Lipid profiles showed a reduction in harmful cholesterol levels in treated groups (p<0.01).
• Histological analysis indicated better kidney structure and reduced damage in treated rats compared to control.