Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens | Synapse
May 8, 2026
Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens
Puntos clave
This research aims to synthesize clausenamide isomers and assess their potential to promote cortical synaptogenesis.
Synthesis of various clausenamide isomers
Evaluation of synaptogenic effects in cortical cultures
Assessment of 5-HT2A receptor activity
-Clausenamide isomer demonstrated the highest level of cortical synaptogenesis
Effect size correlated with its function as a 5-HT2A receptor partial agonist
Resumen
-clausenamide exhibited the highest level of cortical synaptogenesis, with this effect likely being dependent on its ability to act as a 5-HT2AR partial agonist.