Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens

Key Points

• This research aims to synthesize clausenamide isomers and assess their potential to promote cortical synaptogenesis.
• Synthesis of various clausenamide isomers
• Evaluation of synaptogenic effects in cortical cultures
• Assessment of 5-HT2A receptor activity
• -Clausenamide isomer demonstrated the highest level of cortical synaptogenesis
• Effect size correlated with its function as a 5-HT2A receptor partial agonist

Abstract