Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens

Yongyu Ou; Yara A. Khatib; Adam Mosswood; Tarun K. Roy; David A. Gutierrez; David E. Olson; Jared T. Shaw

doi:10.1021/acschemneuro.5c00767

May 6, 2026ACS Chemical Neuroscience

Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens

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Key Points

This research aims to synthesize clausenamide isomers and assess their potential to promote cortical synaptogenesis.
Synthesis of various clausenamide isomers
Evaluation of synaptogenic effects in cortical cultures
Assessment of 5-HT2A receptor activity
-Clausenamide isomer demonstrated the highest level of cortical synaptogenesis
Effect size correlated with its function as a 5-HT2A receptor partial agonist

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Implication

Evaluates cortical synaptogenesis using clausenamide isomers, suggesting promising neuroplastic effects.

Abstract

-clausenamide exhibited the highest level of cortical synaptogenesis, with this effect likely being dependent on its ability to act as a 5-HT2AR partial agonist.

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Ou et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fcdbfa21ec5bbf08722 https://doi.org/10.1021/acschemneuro.5c00767

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Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens

Key Points

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Implication

Abstract

Discussion

Cite This Study

Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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