Physiological thresholds for angina are highly individualized, vary with cardiac workload, and are consistently lower than universal ischemia-based thresholds (P>0.999).
RCT
Double-Blind
Randomized
valor p: p=>0.999
BACKGROUND: ) at rest and during exercise remain undefined. METHODS: values were recorded at symptom onset. The protocol was repeated during low- and high-intensity exercise to assess changes in angina thresholds with increasing cardiac workload. RESULTS: >0.999). CONCLUSIONS: ) are highly individualized, vary with cardiac workload, and are consistently lower than the universal ischemia-based thresholds used to guide revascularization. These findings support integrating personalized, symptom-linked physiology to refine patient selection and to improve symptomatic response to PCI.
Recently featured on the 'Circulation on the Run' podcast, this study challenges the universal ischemic thresholds used to guide PCI. It demonstrates that angina thresholds are highly individualized, sparking debate on how to better select patients for revascularization.
Ahmed-Jushuf et al. (Fri,) conducted a rct in Angina. Physiological threshold assessment vs. Placebo was evaluated on Angina thresholds at symptom onset (p=>0.999). Physiological thresholds for angina are highly individualized, vary with cardiac workload, and are consistently lower than universal ischemia-based thresholds (P>0.999).