April 12, 2007

Highly Enantioselective Insertion of Carbenoids into N−H Bonds Catalyzed by Copper Complexes of Chiral Spiro Bisoxazolines

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Resumen

A highly efficient copper-catalyzed asymmetric insertion of α-diazoesters into N−H bonds has been realized by using chiral spiro bisoxazoline ligands, affording α-amino acid derivatives in high yields with excellent enantioselectivities.

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Liu et al. (Thu,) studied this question.

synapsesocial.com/papers/6a001f68b124fe581985c4db https://doi.org/https://doi.org/10.1021/ja0711765

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5Cu( <scp>i</scp> )-carbenoid- and Ag( <scp>i</scp> )-Lewis acid-catalyzed asymmetric intermolecular insertion of α-diazo compounds into N–H bonds2004 · 151 citations

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