18 F-Labelling of (Hetero)aryl Halides via Sequential Miyaura Borylation/Copper-Mediated Radiofluorination

Puntos clave

• The aim is to develop a reproducible method for the radiofluorination of aryl halides using a sequential approach.
• Utilized a sequential Miyaura borylation and copper-mediated radiofluorination approach.
• Targeted various heteroaryl iodide, bromide, and chloride substrates with palladium catalysis.
• Successfully achieved radiofluorination with over 85% yield for several substrates.
• Demonstrated broad applicability across different (hetero)aryl halide structures.