¹⁸ F-Labelling of (Hetero)aryl Halides via Sequential Miyaura Borylation/Copper-Mediated Radiofluorination

Abdias N. Noel; Samuel G. Greco; Mami Horikawa; Taylor Spiller; Diana Nichols; Jason A. Witek; Allen F. Brooks; Peter J. H. Scott; Melanie S. Sanford

doi:10.1039/d6sc01625a

January 1, 2026Chemical ScienceOpen Access

¹⁸ F-Labelling of (Hetero)aryl Halides via Sequential Miyaura Borylation/Copper-Mediated Radiofluorination

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Key Points

The aim is to develop a reproducible method for the radiofluorination of aryl halides using a sequential approach.
Utilized a sequential Miyaura borylation and copper-mediated radiofluorination approach.
Targeted various heteroaryl iodide, bromide, and chloride substrates with palladium catalysis.
Successfully achieved radiofluorination with over 85% yield for several substrates.
Demonstrated broad applicability across different (hetero)aryl halide structures.

Implication

This Article demonstrates a new method for radiofluorinating aryl halides, suggesting efficient synthesis for imaging applications.

Abstract

This Article describes the development of a mild, general, and highly reproducible method for the radiofluorination of (hetero)aryl iodide, bromide, and chloride substrates. This transformation proceeds via sequential Pd-catalysed Miyaura...

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Cite This Study

Noel et al. (2026) studied this question.

synapsesocial.com/papers/6a002087c8f74e3340f9b705 https://doi.org/10.1039/d6sc01625a

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¹⁸ F-Labelling of (Hetero)aryl Halides via Sequential Miyaura Borylation/Copper-Mediated Radiofluorination

Key Points

Implication

Abstract

Discussion

Cite This Study

¹⁸ F-Labelling of (Hetero)aryl Halides via Sequential Miyaura Borylation/Copper-Mediated Radiofluorination

Key Points

Implication

Abstract

Discussion

Cite This Study

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