This study demonstrates the copper complex's efficiency in trifluoromethylation and 18F-labeling of aryl iodides, highlighting its potential for new radiopharmaceuticals.
Here, we report an efficient and highly active copper complex ([(TMPhen)2Cu(I)][O2CCF2Cl]) for the trifluoromethylation of aryl iodides. This bench-stable copper complex converts aryl iodides into their corresponding CF3 derivatives in high yields within 1 h. The protocol is also well-suited for aromatic [18F]trifluoromethylation, offering a rapid and efficient approach for the development of new radiopharmaceuticals within 20 min.
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Choi et al. (2025) studied this question.
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