November 1, 2024Open Access

Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells

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Resumen

-EP4/EP2 signaling impairs both adaptive and innate immunity in TME by hampering bioenergetics and ribosome biogenesis of tumor-infiltrating immune cells.

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Cite This Study

Punyawatthananukool et al. (Fri,) studied this question.

synapsesocial.com/papers/6a008395e92f4a033c854a98 https://doi.org/https://doi.org/10.1038/s41467-024-53706-3

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4The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction2016 · 810 citations
5MYC as a regulator of ribosome biogenesis and protein synthesis2010 · 982 citations

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