November 1, 2024Nature CommunicationsOpen Access

Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells

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Abstract

-EP4/EP2 signaling impairs both adaptive and innate immunity in TME by hampering bioenergetics and ribosome biogenesis of tumor-infiltrating immune cells.

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Cite This Study

Punyawatthananukool et al. (2024) studied this question.

synapsesocial.com/papers/6a008395e92f4a033c854a98 https://doi.org/10.1038/s41467-024-53706-3

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Abstract

-EP4/EP2 signaling impairs both adaptive and innate immunity in TME by hampering bioenergetics and ribosome biogenesis of tumor-infiltrating immune cells.