Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation

through the enzyme cascade of SOD and CAT. This alleviates hypoxia, prevents oxidative damage, and restores the balance between pro-inflammatory M1 and anti-inflammatory M2 macrophages, reducing inflammation and immune dysfunction. TPP-SAT breaks the "ROS-inflammation-hypoxia" cycle, inhibits alveolar bone resorption, and accelerates periodontal tissue regeneration. This approach offers a promising strategy for treating periodontitis and other chronic inflammatory diseases, with strong clinical potential.