Asymmetric Synthesis of Alkyl Fluorides via Biocatalytic Reduction of α-Fluoroenones and α-Fluoroenoates

Puntos clave

• The main aim is to develop a biocatalytic method for the asymmetric synthesis of alkyl fluorides.
• Utilized ene reductase enzymes for the reduction process.
• Targeted a diverse range of α-fluoroenones and α-fluoroenoates.
• Explored biocatalytic pathways for product formation.
• Successfully synthesized various alkyl fluorides through biocatalytic reduction.
• Demonstrated the efficiency of ene reductase enzymes in achieving asymmetric synthesis.
• Showed broad substrate compatibility with α-fluoroenones and α-fluoroenoates.